From the A20 take the Ring Oost exit (A16 Dordrecht/Breda). Take the Centrum exit. At the traffic lights at the end turn right towards the centre. Follow the Maasboulevard (the river Maas is now on your left) for 4 kilometres: keep on the Maasboulevard, which is later called Boompjes. At the intersection from which you can see the Erasmus bridge on the left, turn right (Schiedamse Dijk). At the first traffic light take a left-hand turn onto Schilderstraat and Witte de Withstraat, which becomes Museumpark. The museum is on your left.
From the A4/A13, exit Rotterdam Centrum, take a right turn at the second traffic lights and follow the Maastunnel signs into the tunnel (2 km). At the sign 'Centrum/ Erasmus MC' (3rd traffic light) turn left (Rochussenstraat). Turn right at the second traffic light (Westersingel). Then take the first road on the right (Museumpark). The museum is on your left.
From the A16 follow signs to 'Ring Oost/Utrecht', then 'Rotterdam Centrum/Capelle a/d IJssel'. Take the Centrum exit and follow signs to the town centre. Drive along the Maasboulevard (the river will be on your left) for 4 kilometres. Stay on the Boulevard, which is later called Boompjes. Turn right at the the intersection where you can see the Erasmus bridge on your left (Schiedamse Dijk). Turn left at the first traffic light (Schilderstraat/Witte de Withstraat). This road becomes Museumpark. The museum is on your left.
For routes from other directions, please check the Routenet Routeplanner.
N.B. As of January 1st 2016, the municipality of Rotterdam will extend the environmental zone. Click here to see what this means for your transportation.